α4 Integrin Antibody Development Service

α4 Integrin antibodies blocking the interaction of integrin located on the surface of immune cells with endothelial cells have been shown profitable effect in the therapeutics of Autoimmune Diseases & Inflammation. Our company provides world-class research services to help you to develop antibodies with high excellent performance, offering the necessary services and materials for the development of therapeutic antibodies for Autoimmune Diseases & Inflammation.

α4 Integrin in Autoimmune Diseases & Inflammation

α4 integrin is one of the glycoprotein receptors responsible for the bi-directionally delivering signals via cell-cell or cell-extracellular matrix interactions. α4 integrin can pair with distinct members of integrins to form heterodimers, as exemplified by coupling with β1 subunit to form α4β1 (VLA-4), which is expressed from monocytes and lymphocytes and involves in the adhesion and transendothelial migration of leukocytes, as well as the orientation of B cells. Additionally, a challenge has been recognized that VLA-4 plays novel roles to be resolved in different cell types or environments, which is predominantly contributed to the structure of α4. Therefore, the development of more specific therapeutic antibodies to inhibit the heterodimers, especially α4 integrin, is an urgent need in Autoimmune Diseases & Inflammation.

Fig.1 The role of integrins and immune cells in the pathogenesis of inflammatory bowel disease (IBD) (Dotan I., et al., 2020)

• α4 Integrin in Inflammatory Bowel Disease 
  The heterodimer α4β1 is appointed to bind with VCAM-1, and heterodimer α4β7 binds to MAdCAM-1. The former receptor-ligand complex guides the memory and effector T cells home to inflammatory regions in intestine, while the latter complex induces a firm aggregation of leukocytes with endothelial cells and subsequent transendothelial migration.

• α4 Integrin in Multiple Sclerosis
  The heterodimer α4β1 acts as a preponderant effector in the development of inflammation of central neural system (CNS). After the binding with VCAM-1, α4β1 mediates the adhesion of leukocytes to the inflamed areas of CNS endothelium. Parallelly, the encephalitogenic T cells expressing α4β1 are assigned to migrate into the white matter of brain, leading to the sustained inflammation.

In addition to the mechanisms associated with α4 integrin, a plenty of other integrins have been found to participate in the process of various autoimmune response. It will be promising to develop targeted therapeutic antibodies for this large intergins family to control the inflammatory response of autoimmune diseases.

Our Services

At least five therapeutic antibodies against α4 integrin have been applied in practice to intervene in the development and slow the progression of autoimmune diseases. Our company provides high-class antibodies development services for α4 integrin and the related proteins as the following workflow: 

Antigen Validation

α4 integrin signaling pathways

Antibody Generation

Antibody Optimization

Antibody Characterization

Antibody Production & Purification

Our advantages

With professional service team and top equipment, and the capability for integrating industry information instantly, our company is devoted to providing all-sided services for the development of therapeutic antibodies to α4 integrin signaling pathways. If you are interested in our services, please contact us for more detailed information. 

Reference

1. Dotan, Iris et al. "The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti-integrin therapies." Medicinal research reviews 40,1 (2020): 245-262.