Autoimmune Disease Model Development Services
Autoimmune disorders pose significant challenges to both humans and animals, prompting intensive and focused research efforts directed towards understanding and combating these conditions. With over 20 years of expertise in the industry, our company has consistently delivered cutting-edge services and research tools to support advancements in autoimmune disease research.
Autoimmune Disease Models in Biomedical Research and Drug Development
Autoimmune disease models have revolutionized the understanding of autoimmune pathogenesis. By inducing autoimmune-like conditions in controlled environments, researchers can carefully observe disease initiation and progression, providing crucial insights into the underlying cellular and molecular mechanisms.
These models have also facilitated the identification and validation of potential therapeutic targets. By studying the effects of various drugs and therapeutics on disease progression in animal models, researchers can assess the potential efficacy and safety of these interventions.
Moreover, autoimmune disease models serve as essential tools in unraveling the interplay between genetic susceptibility and environmental factors in disease development. These models help researchers decipher the complex genetic networks involved in autoimmune diseases and how they interact with external triggers.
Potential mechanisms influencing autoimmune diseases through air pollution exposure
(Zhao Chan-Na, et al., 2019)
Common Animal Models for Autoimmune Disease
| Models | Diseases | |
|---|---|---|
| Mouse | EAE, SJL/J | Multiple sclerosis (MS) |
| NZM, NZB/W, BXSB, MRL-Faslpr, MRL-Fas+/+ | Systemic Lupus/nephritis | |
| NOD | Type 1 Diabetes | |
| CIA | Arthritis | |
| NFS/sld mutant | Sjögren’s Syndrome | |
| BALB/c mutant | Psoriasis | |
| TNBS-induced | Inflammatory Bowel Disease | |
| OXA | Atopic Dermatitis | |
| OVA | Asthma | |
| NZB/kl | Autoimmune Inner Ear Disease | |
| Rat | NOD | Type 1 Diabetes |
| PGPS-induced | Arthritis | |
| Rabbit | Transgenic or originally generated | Autoimmune Inner Ear Disease |
| Chicken | OS | Autoimmune thyroiditis |
Animal models with a single etiology for developing autoimmune disease manifestations can serve as a platform to invent diagnostic tools and novel therapies targeting that particular etiological factor. Furthermore, the direct and accurate implantation of the genes causing autoimmune diseases into cells can lead to the development of a series of new therapeutic approaches for those diseases in the future.
What We Provide
Various animal models of disease are used to understand the pathogenesis and etiology of autoimmune disease. Our company provides modeling service which can be customized by customer needs. Our autoimmune disease models cover but not limited to the following diseases.
- Asthma
- Atopic Dermatitis
- Type 1 diabetes
- Multiple Sclerosis
- Systemic lupus erythematosus
- Autoimmune pancreatitis
- Inflammatory bowel disease
- Rheumatoid arthritis
- Psoriasis
By harnessing the power of advanced technologies and leveraging its expertise, we continue to make remarkable strides in revolutionizing autoimmune disease research and ultimately improving outcomes.
Cell-Based Model Development Service
Animal Model Development Service
Organoid Model Development Service
Our company is committed to fulfilling all your demands in the research of autoimmune disease. We provide high-quality reagents, one-stop services and comprehensive solutions to support your innovative discoveries. We guarantee to deliver our products and services on time. Please feel free to contact us.
Reference
- Zhao, Chan-Na et al. "Emerging role of air pollution in autoimmune diseases." Autoimmunity reviews 18,6 (2019): 607-614.