Cell-Based Model Development Service
The development of accurate and reliable cell models for studying autoimmune diseases has become paramount in advancing our understanding of these complex disorders and facilitating the development of targeted therapeutics. With over 20 years of experience in the industry, our company is a leading player in this crucial area of research. We provide high-quality reagents, one-stop services and comprehensive solutions to support your innovative discoveries.
Cell Models for Autoimmune Disease
Cellular models have been instrumental in deciphering the molecular and cellular mechanisms underlying autoimmune diseases. These models allow researchers to simulate disease conditions in vitro and explore potential therapeutic interventions.
Variation occurs at each step in an iPSC-based study. (Volpato V., et al., 2020)
Embryonic Stem Cell (ESC) & Induced Pluripotent Stem Cell (iPSC) Models
Embryonic stem cells (ESCs) derived from the inner cell mass of a blastocyst are pluripotent stem cells with unique properties of pluripotency and self-renewal. They can divide indefinitely in vitro, while maintaining the capacity to generate all the cell types of an adult organism. iPSC technology allows the generation of specific pluripotent stem cells from somatic cells. These iPSCs can be differentiated into various immune cell types, offering a personalized approach to study autoimmune diseases. iPSC-derived models have the advantage of capturing individual variations in disease manifestation and response.
Primary Cells & Cell Lines
Patient-derived primary cells are isolated directly from individuals with autoimmune diseases. These cells represent the most authentic reflection of the individual's immune system and disease pathology. For example, related to various autoimmune disease, CD4+ T cells have been studied in functional characteristics, response to specific stimuli, and interactions with other cell types.
Cell lines derived from human or animal models, such as mice and rats, have been extensively used in autoimmune disease research. These cell lines enable scientists to study immune cell interactions, cytokine signaling, and molecular pathways associated with autoimmune diseases.
Autoimmune diseases are often studied in animal models, which cannot replicate the complex biological interactions that play a role in these multifactorial diseases in humans. Human-based alternative methods represent more efficient options to elucidate disease mechanisms and discover potential drug targets.
What We Provide
With the fully tested technical expertise in gene editing and autoimmune disease research, our company provides cell-based model development service to modeling autoimmune disease based on the requirement of the clients. Our cell cell-based model development services include but not limited to the followings.
iPSC Development
- Various diseases (e.g., Type 1 diabetes, Myasthenia Gravis, Autoimmune Demyelinating Neuropathies)
- Conditional differentiation
- With/without mutation
- Human-derived or animal-derived
Primary Cells & Cell Line Development
- Primary cells (PBMCs, eosinophils, neutrophils, monocytes, B cells, T cells, etc.)
- Cell lines (THP1, Jurkat, Raw264.7, etc.)
- Knock-out (Gene deletion, frameshift)
- Knock-in (Point mutation, large insertion)
- Human-derived or animal-derived
Workflow of Cell-Based Model Development
Our company is committed to fulfilling all your demands in the research of autoimmune disease. We provide high-quality reagents, one-stop services and comprehensive solutions to support your innovative discoveries. We guarantee to deliver our products and services on time. Please feel free to contact us.
Reference
- Volpato, Viola, and Caleb Webber. "Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility." Disease models & mechanisms 13,1 (2020): dmm042317.