Animal Model Development Service
In the pursuit of understanding and combatting autoimmune disorders, the development of robust and reliable animal models is crucial. Our company, a leading biotechnology company with over two decades of experience in the industry, stands at the forefront of autoimmune disease animal model development.
Animal Models in Autoimmune Disease Research
Numerous animal models currently serve as valuable tools for investigating etiologic agents, the impact of chemical exposure, and therapeutic efficacy in the context of autoimmune diseases. While a wide range of animal species, including primates, dogs, pigs, chickens, and rabbits, has been utilized in autoimmune disease research, rodents predominantly take center stage in this discourse.
The rodent models can be broadly classified into three categories:
- Genetically predisposed animals.
- Animals in which disease is induced through immunization with specific antigens.
- Animals in which the disease is organically or chemically induced.
Within each of these model types, the manifestation and severity of symptoms are subject to multiple influencing factors, encompassing the genetic composition of the animal, its age, as well as hormonal and environmental variables.
Genome editing methods in animal models (Lee H., et al., 2020)
Technologies for Animal Model Development
CRISPR/Cas9 Genome Editing
CRISPR/Cas9 has emerged as a powerful tool for precise gene editing, enabling researchers to manipulate the genomes of various organisms, including mice and rats, with unparalleled efficiency. This technology has significantly accelerated the generation of animal models for autoimmune disease studies. By targeting specific genes associated with autoimmune disorders, scientists can create genetically modified animals that closely mimic human disease conditions.
Humanized Animal Models
To bridge the gap between preclinical studies and human diseases, humanized animal models have gained prominence in recent years. These models involve introducing human genes or immune cells into animals, allowing researchers to study disease processes in a more relevant context.
We recognize the critical role of well-characterized animal models in understanding the complex mechanisms underlying autoimmune diseases. To facilitate robust research, we offer a comprehensive range of characterization services for autoimmune disease animal models.
What We Provide
Our company specializes in the design and engineering of animal models that accurately mimic human autoimmune conditions. It is our mission to develop relevant and predictive models for various autoimmune disorders by combining innovative genetic engineering techniques (CRISPR/CAS9) and immunological insights. We also offer chemically induced animal models, such as colitis and rheumatoid arthritis models.
Gene Engineered Animal Models
- Targeting specific autoimmune disease genes
- Accurate editing to meet customer's needs
- Abundant species to select (mouse, rat, rabbit, chicken, etc.).
Chemically Induced Animal Models
- Injected with chemicals
Exposure to harmful substances - Proficient operating platform
Other Animal Models
- Spontaneous animal models
- Diet-induced animal models
We offer comprehensive characterization services to validate the fidelity of autoimmune disease animal models. This includes rigorous phenotypic and genotypic evaluations to ensure that the generated models exhibit the desired disease traits and pathological manifestations.
Workflow of Autoimmune Disease Animal Model Generation
Our company is committed to fulfilling all your demands in the research of autoimmune disease. We provide high-quality reagents, one-stop services and comprehensive solutions to support your innovative discoveries. We guarantee to deliver our products and services on time. Please feel free to contact us.
Reference
- Lee, Hyunji et al. "Genome editing methods in animal models." Animal cells and systems 24,1 (2020): 8-16.