B-cell Therapy Development Service
B-cell therapy involves using techniques to modify or harness the B lymphocytes to modulate the immune response and reduce inflammation in conditions where the immune response is overactive. Our company provides best-in-class research services and experimental materials to accelerate your development of highly effective therapeutic B cells for the treatment of Autoimmune Diseases & Inflammation.
B-cell Therapy in Autoimmune Diseases & Inflammation
B cells are a type of white blood cell staying in the bone marrow for decades that plays a crucial role in the immune system by not only producing antibodies, but also secreting immune modulating factors. Memory B cells, formed after, possess long-term immunological memory. On being activated to transform into plasma cells, they can secrete high concentrations of particular antibodies and perform immune functions. With several advantageous functional mechanisms, engineered B cells have received increasing attention as one of the options for immunotherapy:
Fig.1 Potential features of engineered B cells as an immune cell therapy (Rogers G.L., et al., 2021)
- B cells exist and maintain the activity for a long time, providing a long-lasting therapeutic effect.
- B cells can interact with other cells in the immune system through regular cytokine exchange.
- They can also directly interact with CD4+ T cells through antigen presentation, or indirectly facilitate dendritic cells in presenting antigen-antibody complexes to T cells.
- B cells, which mainly drive humoral immunity, have a longer surveillance power than the cellular immune response by T cells.
In combination with the above advantages, B cells have been used to pretreat in vitro to enhance the efficacy of their immune response, and exert significant therapeutic effects after reinfusion in vivo, suggesting that B cells have great potential as alternative engineering cell therapy for Autoimmune Diseases & Inflammation.
Our Services
B-cell therapy is based on the creation of cells that can produce engineered specific antibodies and simultaneously have the ability to remember and respond to cognate antigens. Our company provides way-ahead development service for B-cell therapy as the following workflow:
We provide selectable strategies for B cells engineering including but not limited to:
- The specific antigen is fused to the heavy chain of IgG, resulting in the modification of B cells to become immune tolerant antigen-presenting cells.
- Using lentiviral vectors to insert exogenous therapeutic proteins (e.g., factor IX), into the specific promoters of in vitro modified B cell to provide B cells with a long-acting source of therapy.
- Applying CRISPR-Cas9 system to precisely insert exogenous therapeutic proteins into specific sites, so that B cells can stably express the desired protein for a long time.
Our Advantages
- Specific services on a case-by-case basis
- Rigorous experimental operation and analysis
- Laboratories equipped with state-of-the-art instruments
- Thorough experimental analysis with explicit data
With a group of experienced cellular immunology experts and cell engineering researchers, our company is wholeheartedly bound up in providing comprehensive services to facilitate the development of engineered therapeutic B cells for Autoimmune Diseases & Inflammation. Please contact us for more detailed information and our team will get back to you promptly.
Reference
- Rogers, Geoffrey L, and Paula M Cannon. "Genome edited B cells: a new frontier in immune cell therapies." Molecular therapy 29,11 (2021): 3192-3204.