Biomarker Development Services
Biomarkers can serve as important indicators for the prediction, progression and prognostic testing of autoimmune diseases and inflammation. Our company provides leading-edge research services and essential platforms to help you get ahead of the curve in the biomarker development for Autoimmune Diseases & Inflammation.
Overview of Autoimmune Diseases & Inflammation
Autoimmune diseases are a group of pathological processes in which the body's immune system abnormally attacks its own tissues and organs, thereby triggering inflammatory reactions and tissue damage, and their pathogenesis involves abnormalities in cytokines, autoantibodies, immune cells, and other immune factors of the body. Classical autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjögren syndrome (SS), are often associated with a characteristic autoantibody profile. The associated autoantibody profile is not only a diagnostic criterion for the classification of the disease, but may also correlate with the degree of disease activity and prognosis.
Fig.1 Potential biomarkers in extracellular vesicles (EVs) for autoimmune diseases (Xu K., et al., 2020)
Common Biomarkers for Autoimmune Diseases & Inflammation
For autoimmune diseases & Inflammation, in addition to the characteristic autoantibody profile associated with them, there are other types of common biomarkers as follows:
Autoantibody Biomarkers
Since the production of autoantibodies is one of the essential features of autoimmune diseases, autoantibodies themselves thus become serological biomarkers for most autoimmune diseases. Early diagnostics is important in the management of autoimmune diseases. Detecting autoimmune disease at an early stage can prevent or delay irreparable damage to the underlying organ or tissue.
Cytokine Biomarkers
In autoimmune diseases, the abnormal secretion and action of cytokines are not only directly involved in the development of the disease, but also affect the balance of the body's immune status. Autoimmune diseases are usually related to the abnormal secretion of a variety of cytokines, among which tumor necrosis factor-alpha, IL-6, IL-8, and IL-10 are the most typical and commonly used serum biomarkers.
MicroRNA Biomarkers
MicroRNA are a novel class of disease biomarkers discovered in recent years, which can be found in serum and other body fluids. More importantly, secreted miRNAs, especially those secreted by extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues, thereby regulating gene expression and remotely modulating cellular functions.
Lymphocyte Biomarkers
In some autoimmune diseases, representative lymphocyte subpopulations are induced. Therefore, specific lymphocyte types can also serve as biomarkers for autoimmune diseases and as key indicators for diagnostic testing in the clinic for early screening, disease course monitoring, and drug efficacy assessment.
Our Services
Autoimmune diseases are a group of diseases triggered by the immune system's immune response to its own components. The pathogenesis of the different types of autoimmune diseases is very complex, which poses a great challenge to the diagnostics of autoimmune diseases. Our company provides biomarker development services with the support from multidisciplinary experts and utilization of various technological platforms, including but not limited as:
Genomics-based Biomarker Discovery Platform
- Through genomics technology, the sequence of the target DNA is analyzed to look for genetic variants associated with the disease.
Transcriptomics-based Biomarker Discovery Platform
- Through transcriptomics technology, we study the expression patterns of disease genes using microarray or RNA sequencing methods.
Proteomics-based Biomarker Discovery Platform
- Through proteomics technology, mass spectrometry or protein microarrays are used to identify and quantify differential proteins in biological samples.
Metabolomics-based Biomarker Discovery Platform
- Through metabolomics technology, small molecule metabolites are analyzed to understand the changes in metabolites associated with disease.
Workflow for Biomarker Development
Bioinformation Collection
Bioinformation Analysis
Biomarker Identification
Biomarker Confirmation
Staffed by the researchers from cell engineering biology and immunology with extensive experience in the development of successful diagnostic development, our company is committed to providing you with professional services for the biomarker development of Autoimmune Diseases & Inflammation. If you are interested in our services, please don't hesitate to contact us.
Reference
- Xu, Kaiyuan et al. "Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases." Journal of translational medicine 18,1 (2020): 432.