CAR-T Therapy Development Service

Chimeric antigen receptor T cells (CAR-T cells) are T cells genetically engineered to introduce a gene encoding a specific antigen receptor, which have been applied in the therapeutics of various malignancies and autoimmune diseases. Our company provides cutting-edge research services to help you rapidly design and develop CAR-T cell therapies with high efficacy for Autoimmune Diseases & Inflammation.

CAR-T Therapy in Autoimmune Diseases & Inflammation

The excessive activity of immune system is featured by autoreactive T lymphocytes in autoimmune diseases, which recognize the receptor complex located on the surface of target cells. The regular immunosuppressive therapy has the disadvantages of low specificity and relatively strong side effects, resulting in poor therapeutic effect. The emergence and evolution of CAR-T cells have promoted the therapeutics of autoimmune diseases to a new time.

T cells genetically engineered to express CAR are termed as CAR-T, which has shown remarkable of targeting specificity and persisting capabilities in bodies for a considerable period. The development of CAR-T cells is in continuous evolution. The latest version of CAR-T cells no longer depends on MHC molecules. The assembled multiple stimulatory domains can greatly transmit the activation information of T cells and enable T cells to maintain long-lasting cell killing ability. In addition, the load of exogenous DNA to be transfected into T cells has been greatly increased, providing more space for the modification increased specificity of CARs for T cells.

Fig.1 Workflow of anti-CD19 CAR-T cell therapy for systemic lupus erythematosus.  (Jin X., et al., 2021)

At present, CAR-T cell therapies has shown excellent effects in a few kinds of animal models and clinical trials of autoimmune diseases. In the experimental therapeutics of systemic lupus erythematosus, patients received CD19 CAR-T cell transfer show marked B-cell depletion, leading to symptom resolution. According to the latest research progress, non-viral methods to construct CAR-T cells have been introduced into therapeutic trials for Sjogren's syndrome, which will be more excellent in the retention of healthy B cells and targeting specificity. It is predictable that CAR-T cell therapy will fill the unmet therapeutics paradigm for Autoimmune Diseases & Inflammation.

Our Services

CAR-T cell therapy is a revolutionary approach of immune cell therapy with chimeric antigen receptors that accurately identify abnormal cells in Autoimmune Diseases & Inflammation. Our company provides an up-to-the-minute package of cell services for CAR-T cell therapy development as the following workflow:

We provide the CAR design services for antibody targets including but not limited to:

Our Advantages

With the participation of senior researchers with expertise in molecular biology and cell engineering, and equipped with a complete set of cell engineering experimental platform, our company is committed to providing considerate services for the development of therapeutic CAR-T cells for Autoimmune Diseases & Inflammation. Please contact us for more detailed information and our team will get back to you promptly.

Reference

1. Jin, Xuexiao et al. "CAR-T cell therapy: new hope for systemic lupus erythematosus patients." Cellular & molecular immunology 18,12 (2021): 2581-2582.