Diagnostic Kit Development Services
Autoimmune diseases are often regarded as complex diseases due to their extremely complicated causes and symptoms. Therefore, the development of new diagnostic technologies for autoimmune diseases is considered to be very promising. Our company provides leading-edge research services and essential platforms to help you get ahead of the curve in the diagnostic kit development for Autoimmune Diseases & Inflammation.
Overview of Diagnostic Kit for Autoimmune Diseases & Inflammation
In recent years, due to the rapid development of technology in the field of in vitro diagnostics, many new biomarkers for autoimmune diseases have been applied in practice and play an important role in diagnosis. Depending on the type of biomarker, these autoimmune disease biomarkers can be matched with different kit assays to meet the rapid detection needs of preclinical studies.
Fig.1 Mechanisms of immune-mediated glomerulonephritis (Pisetsky D.S., 2023)
Types of Diagnostic Kit for Autoimmune Diseases & Inflammation
For the detection and diagnosis of Autoimmune Diseases & Inflammation, there are several most common types of test kits as follows:
Autoantibody Test Kits
Autoantibodies are characteristic biomarkers of autoimmune diseases, which are important for the diagnostics, identification, and therapy monitoring of associated diseases. For example, screening for antinuclear antibodies (ANA) against the nucleus is commonly used to diagnose systemic lupus erythematosus (SLE), and detection of rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) can be used to diagnose rheumatoid arthritis.
Complement Test Kits
Complement is a serum protein that can be activated by antigen-antibody complexes or microorganisms to mediate the body's immune response and inflammatory reactions. Abnormal complement levels may signal the onset of certain autoimmune diseases. For example, the detection of C3 and C4 complement levels can be used to assess the activity of complement proteins in systemic lupus erythematosus disease.
Inflammatory Marker Test Kits
Autoimmune diseases are usually accompanied by a strong and persistent inflammatory response, so the detection of some inflammatory markers can also provide a valuable reference for the diagnosis of autoimmune diseases. For example, the classic C-reactive protein (CRP) test can be used to assess the level of inflammation in autoimmune diseases.
Potential Biomarkers for Diagnostic Kit Development of Autoimmune Diseases
| Autoimmune Diseases | Biomarkers for Diagnostic Kit Development |
|---|---|
| Autoimmune Hepatitis | Transforming Growth Factor-beta (TGF-ß1) |
| Tumor Necrosis Factor-α (TNF-α) | |
| Tumor Necrosis Actor Family B-cell Activating Factor (BAFF) | |
| Macrophage Migration Inhibitor Factor (MIF) | |
| Anti-asialoglycoprotein Receptor Antibodies | |
| Adenosine Deaminase (ADA) | |
| Autoimmune Disease Related to Central Nervous Systems | Neurofilament Light Chain |
| Neuron Specific Enolase | |
| Glial Fibrillary Acid Protein (GFAP) | |
| Contactin-1 (CNTN-1) | |
| Chitinase-3-Like Protein 1 (CHI3L1) | |
| Kappa Free Light Chain (KFLC) | |
| Anti-AQP4-Antibody (AQP4-IgG) | |
| Chemokine (C-X-C motif) Ligand 13 (CXCL13) | |
| Autoimmune Disease Related to Otolaryngology | Anti-Cogan Peptide Antibody |
| Anti-HSP70 Antibody | |
| Immunoglobulin G 4 (IgG4) | |
| Soluble Interleukin 2 | |
| Anti-thyroid Peroxidase Antibody | |
| Thyroid Stimulating Hormone Receptor Antibody |
Our Services
Nowadays, the development of novel diagnostic technologies is an integral part of the field of basic disease research, but there is still a lack of development programs for Autoimmune Diseases & Inflammation. Our company provides diagnostic kit development services with the support from multidisciplinary experts and utilization of various technological platforms, including but not limited as:
Biochemistry Diagnostic Kits
- Blood Enzymes Index Test Kit
- Blood Ions Index Test Kit
- Blood Lipids Index Test Kit
Immunodiagnostic Kits
- Fluorescence Immunochromatography Assay Kit
- Colloidal Gold Immunochromatographic Assay Kit
- Enzyme-Linked Immunosorbent Assay Kit
- Chemiluminescence Immunoassay Kit
Molecular Diagnostic Kits
- Single Gene Test Kit
- Genomic Sequencing Kit
Workflow for Diagnostic Kit Development
Diagnostic Kit
Target Determination
Diagnostic Kit
Construction
Diagnostic Kit
Assembly
Diagnostic Kit
Validation
Staffed by the researchers from cell engineering biology and immunology with extensive experience in the development of successful diagnostic development, our company is committed to providing you with professional services for the diagnostic development of Autoimmune Diseases & Inflammation. If you are interested in our services, please don't hesitate to contact us.
Reference
- Pisetsky, David S. "Pathogenesis of autoimmune disease." Nature reviews. Nephrology 19,8 (2023): 509-524.