In Vitro Physicochemical Studies
In the realm of pharmaceutical research and development, understanding the physicochemical properties of drug candidates is crucial for their successful formulation and efficacy. Our company has extensive experience and the ability to provide quality in vitro physical and chemical research services to accelerate the development of drugs and therapies for immune diseases and inflammation.
Overview of In Vitro Physicochemical Study
In vitro physicochemical study involves a range of experimental techniques that assess the physicochemical properties of drug substances. These properties include solubility, dissolution rate, permeability, stability, and various other factors that influence drug formulation and delivery. By conducting these studies in a controlled laboratory setting, researchers can evaluate the behavior of drug candidates, analyze their molecular interactions, and predict their behavior in vivo.
Fig. 1 An example of the determination of inactivation kinetic parameters. (Choi S., et al., 2022)
In Vitro Physicochemical Study for Autoimmune Diseases and Inflammation
Drug Formulation and Delivery
Understanding the physicochemical properties of drug candidates is crucial for formulating effective drug products. In vitro physicochemical studies help identify suitable excipients, optimize drug solubility, and assess drug release profiles. This information is essential for developing drug delivery systems that ensure optimal drug concentrations at the target site, enhancing therapeutic outcomes in autoimmune diseases and inflammation.
Bioavailability Enhancement
Poor solubility and permeability often hinder the bioavailability of drug candidates. In vitro physicochemical studies evaluate the dissolution rate, solubility, and permeability of drugs, aiding in the identification of strategies to overcome these challenges. By enhancing drug bioavailability, the efficacy of therapies for autoimmune diseases and inflammation can be significantly improved.
Stability Assessment
Autoimmune diseases and inflammation require chronic treatment, necessitating drug stability over an extended period. In vitro physicochemical studies enable the evaluation of drug stability under various conditions, including temperature, humidity, and pH variations. These studies help identify potential degradation pathways, enabling the development of stable formulations for long-term therapeutic use.
Our Services
At our company, we offer comprehensive in vitro physicochemical study services tailored to the specific needs of drug development in autoimmune diseases and inflammation. Our experienced scientists use state-of-the-art equipment and techniques to provide accurate and reliable data as well as after-sales support.
Aqueous Solubility Assays
- Kinetic solubility assay
- Thermodynamic solubility assay
Lipophilicity (Log D and Log P) & pKa
- Potentiometric titration
- Reversed-phase high-performance liquid chromatography (RP-HPLC)
- Thin-layer chromatography (TLC)
Chemical Stability (pH, SGF, and SGF)
- Accelerated stress studies
- Forced degradation studies
- Photostability testing, stability storage
- Degradation products testing
With a focus on efficiency and rational formulation design, we strive to support the development of effective therapies that address the challenges posed by autoimmune diseases and inflammation. If you are interested in our services, please don't hesitate to contact us.
Reference
- Choi, Suein, Dong-Seok Yim, and Soo Hyeon Bae. "Prediction of metabolizing enzyme-mediated clinical drug interactions using in vitro information." Translational and Clinical Pharmacology 30.1 (2022): 1.