Macrophage Therapy Development Service
Macrophage therapy refers to an immunotherapy that optimizes the natural abilities of macrophages to improve the body's immune response. There are only a dozen clinical trials of macrophage-based therapies for various tumors and chronic diseases. Our company provides state-of-the-art research services and high-quality experimental platforms to enhance the development of highly effective macrophages therapies in accordance with your request for the therapeutics of Autoimmune Diseases & Inflammation.
Macrophage Therapy in Autoimmune Diseases & Inflammation
Macrophage belonging to the family of white blood cells plays essential roles in innate immunity and adaptive immunity. After recognizing and responding to pathogens, macrophages secret cytokines and chemokines and recruit various immune cells to create a pro-inflammatory environment. Further, macrophages present antigens to T cells to promote adaptive immune response. The role of macrophages as a bridge between innate/adaptive immunity makes them a high-potential therapeutic option for blocking the development of autoimmune diseases.
Fig.1 The abnormal functions of macrophage in systemic sclerosis (Yang S., et al., 2023)
In autoimmune diseases, macrophages basically cause damage to the body's own cells and tissues through a variety of mechanisms found in systemic lupus erythematosus, systemic sclerosis and rheumatoid arthritis:
- Macrophages infiltrate into the inflammatory areas to promote the production of Th17 cells and release of pro-inflammatory factors, such as IL-10, growth factors and chemokines.
- The phagocytic ability of macrophages is impaired, leading to the generation of autoantibodies.
- The autophagy and apoptosis of macrophages increase significantly in autoimmune contexts.
- Functionally defective macrophages induce the barrier to the clearance of apoptotic substances.
- The abnormal activation of M1 macrophages involves in pro-inflammatory status, restraining the activation of M2 macrophages which are anti-inflammatory.
Understanding these mechanisms, combined with the unique property of macrophages to actively seek out targets in the body, the development of macrophage therapeutics has attracted attention to its feasibility and potential.
Our Services
Macrophages therapy involves altering or exploiting the function of macrophages, which has been shown specificity, targeting and minimized side effects in multiple disease models. Our company provides way-ahead development service for macrophages therapy as the following workflow:
We provide selectable strategies for macrophages therapies including but not limited to:
- Differentiating stem cells to macrophages ex vivo and transplanting these cells back into the vivo.
- Nanoparticles carrying
therapeutic agents are engineered to directly target macrophages.
- Macrophages are modified with CAR of different versions to increase therapeutic efficacy.
- Regulate macrophages from the M1 to M2 polarization to form properties that inhibit inflammation.
Our Advantages
- Customer-centered personalized services
- Fast development cycle with strict process
- Global instant online services
- Mature development and application procedure
With participation of professional service team and first-class complete facilities and equipment, and the capability to instantly perceive the industry information, our company is fully committed to providing comprehensive services to accelerate the development of engineered therapeutic macrophages for Autoimmune Diseases & Inflammation. Please contact us for more detailed information and our team will get back to you promptly.
Reference
- Yang, Shuang et al. "Macrophage: Key player in the pathogenesis of autoimmune diseases." Frontiers in immunology 14 (2023) 1080310.