PBMCs
Peripheral Blood Mononuclear Cells (PBMCs) are a critical component of the human immune system, encompassing lymphocytes and monocytes. These cells are pivotal in the body's defense mechanisms, with lymphocytes engaged in adaptive immunity and monocytes in innate immunity. In the context of autoimmune diseases, where the immune system mistakenly attacks the body's own tissues, PBMCs play a dual role—both as culprits and as targets for therapeutic intervention.
At Protheragen, we specialize in providing high-quality PBMCs for the development of drugs and therapies targeting autoimmune diseases. Our commitment to excellence is reflected in our rigorous standards for product quality, customization, and ethical sourcing.
Standardized PBMC Isolation and Cryopreservation
We employ stringent, standardized protocols to isolate PBMCs from whole blood, ensuring the highest levels of purity and viability. The isolated cells are then cryopreserved using specialized freezing media, allowing for long-term storage and preservation of cellular function—a critical requirement for in-depth investigations into autoimmune pathogenesis.
Diverse Donor Profiles for Comparative Studies
Protheragen's extensive network of clinical collaborators provides access to PBMC samples from a wide range of donors, including both healthy individuals and those diagnosed with various autoimmune disorders. This diversity enables our research partners to conduct comparative studies, gaining invaluable insights into the unique immunological profiles associated with different autoimmune conditions.
Customizable Specifications for Tailored Research
To meet the specific requirements of our clients, Protheragen offers the flexibility to customize PBMC sample attributes, such as cell concentration, freezing medium, and packaging formats. This level of customization ensures that our partners receive the samples that best align with their autoimmune research objectives, whether they are investigating disease mechanisms, evaluating novel therapeutic targets, or developing personalized therapeutic approaches.
Product Information
| Viability | Viability is a key parameter in PBMCs products, with Protheragen guaranteeing an average cell viability of ≥95%. This high standard ensures that the cells retain their functional integrity, making them suitable for a wide array of applications. |
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| Quantity and Concentration | Each vial of PBMCs from Protheragen contains at least 1×10^7 cells, providing researchers with a substantial starting material for their projects. We also offer customization in terms of cell concentration and freezing media to meet specific experimental requirements. |
| Processing and Storage | Our PBMCs are processed within 2-3 hours post-collection and frozen within 4 hours, ensuring optimal preservation of cell viability. Storage is maintained at temperatures between -140°C and -180°C in the vapor-phase of liquid nitrogen, guaranteeing at least 60% viability post-thaw. |
Product Features
- Customization and Personalization: Protheragen prides itself on the ability to customize PBMCs products to meet specific research needs. This includes further isolation into T cells, B cells, and/or NK cells, as well as HLA typing, which is crucial for personalized medicine approaches in autoimmune disease research.
- Simultaneous Collection of Plasma or Serum: In addition to PBMCs, Protheragen can collect fresh plasma or serum simultaneously, providing a comprehensive suite of samples for researchers studying the interplay between immune cells and the soluble factors in autoimmune diseases.
- Downstream Analysis Support: We understand that research extends beyond the collection of samples. Protheragen supports downstream analysis by performing additional laboratory services on the isolated PBMCs according to custom needs and protocols, ensuring seamless integration with our clients' research programs.
Protheragen is at the forefront of providing PBMCs products that are integral to the development of autoimmune disease drugs and therapies. Our commitment to quality, customization, and ethical sourcing, combined with our product features and the diversity of our PBMCs offerings, positions us as a trusted partner in the quest for novel therapeutics. If you are interested in our products, please don't hesitate to contact us.