Preclinical Studies Service

Preclinical studies involve a train of investigations, tests, and evaluations that precede clinical trials to collect data on the safety, operability, and iterative effectiveness and efficiency of a drug product in experimental animals. Our company provides you with professional preclinical research services to accelerate the evaluation of efficacy and safety for your candidate drug in Autoimmune Diseases & Inflammation.

Preclinical Studies in Autoimmune Diseases & Inflammation

Absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) are five critical characteristics used to determine whether a drug is viable. Pharmacokinetics (PK) reflects the process of how the body interacts with a drug between the duration from entering the body to being excreted. Assessment studies of the ADME characteristics on in vitro and in vivo models guide the experimental design and data analysis of PK tests, which in turn validate and complement the conclusions of the ADME assessment, to ultimately determine whether the drug under test is a candidate for subsequent program. Typically, many Autoimmune Diseases & Inflammation share an underlying pathophysiological mechanism, triggered by an overactive or abnormal immune system response. The ADME-Tox and PK assessments provide suggestions for a roughly identical direction to guide the improvement of drug feature.

Fig.1 Architecture of ADME/PK assessments

Pharmacodynamics (PD) Biomarker in Autoimmune Diseases & Inflammation

Pharmacodynamics is about how drugs work and how it shows its function through biochemical, physiological, and molecular effects on the body. Different biomarkers of inflammation can be used as the indicators of pharmacodynamics to determine the efficacy and safety of small molecule drugs in models with Autoimmune Diseases & Inflammation during administration.

Our Services

Preclinical Studies aims at fully understanding the potency and effects of drugs in the body. Our company provides you with professional and meticulous preclinical studies services for drug development related to Autoimmune Diseases & Inflammation. Our services include but are not limited to:

We accept any type of biological samples for the above bioanalysis and provide corresponding testing services.

Whole Blood
Plasma
Serum
CSF
Organ Tissues

Bioanalysis

Fluoro Enzyme
ECL
ELISA
Spectrometer
HPLC-MS/MS

Our Advantages

With the integration of senior engineers and experimentalists, our company will help you make comprehensive preclinical studies for the effect and toxicity of your small molecule candidates and reduce the potential risk in Autoimmune Diseases & Inflammation. If you are interested in our services, please contact us for more detailed information.