Probiotic Therapy Development Services
Probiotic therapy aims to provide the human body with live beneficial bacteria through supplements or fermented foods, maintaining a healthy balance of microorganisms in the digestive system of human body. Our company is committed to providing cutting-edge research services and comprehensive trial platforms to help you accelerate the development of probiotic therapy for Autoimmune Diseases & Inflammation.
Probiotic Therapy in Autoimmune Diseases & Inflammation
Autoimmune diseases caused by environmental factors are expanding among humans. Increasing evidence suggests that the imbalance in the composition and function of the gut microbiota is one of the environmental factors contributing to autoimmune diseases. The gut microbiota of patients with various autoimmune diseases has been found to significantly differ from that of healthy individuals. Beyond gastrointestinal diseases like inflammatory bowel disease, there are also non-gastrointestinal diseases, such as rheumatoid arthritis and Sjögren's syndrome. These imbalances in the microbiota contribute to abnormalities in the host's immune system function. In-depth research into the connection between the microbial community and autoimmune responses will provide valuable insights for identifying precise and personalized probiotic therapeutic approaches.
Fig.1 Schematic representation of the interaction between host intestinal immune cells and probiotics (Mazziotta C., et al., 2023)
Through a series of studies, the mechanisms by which gut microbiota play a role in autoimmune diseases have been preliminarily elucidated. Utilizing probiotics in the diet to enhance both innate and adaptive immune responses in the digestive system and throughout the body has become the most convenient approach. This not only improves the absorption efficiency of nutritional components in food but also reduces the intolerance of certain food components in sensitive individuals.
Regulate Abnormal Settlement of Microbial
In some autoimmune diseases, microbes that are normally present in the gut can appear in other organs. This abnormal relocation of microbes results in inflammation reactions in the tissues at the new location caused by the derivatives of these microbes. Utilization of probiotics can alleviate local irritations caused by such microbial imbalances.
Regulate Disrupted Immune Responses
Imbalances in the microbial community and metabolic products within the gut can lead to a disturbance of immune cell types and quantities, resulting in the production of numerous pro-inflammatory cytokines. While the probiotics would enhance immune function by inducing the production of IgA antibodies by B cells in the intestine.
Our Services
Probiotic therapy has achieved considerable results in regulating the immune system, affecting immune tolerance and maintaining mucosal barrier in Autoimmune Diseases & Inflammation. Our company provides probiotic therapy development services with the support of microbiology experts and utilization of technological platforms from various disciplines. We therapeutic development services for a variety of probiotics, including but not limited as:
- Lactobacillus Rhamnosus
- Bifidobacterium Adolescentis
- Lactobacillus
- Saccharomyces Boulardii
- Escherichia Coli Nissle 1917
- Akkermansia Muciniphila
- Faecalibacterium Prausnitzii
- Akkermansia Muciniphila BAA-835
- Collinsella Aerofaciens VPI 1003
- Prevotella Copri JCM 13464
- Segmented Filamentous Bacteria
Workflow for Probiotic Therapy Development
Solation and Identification
Gene Editing & Verification
Physiological Application
Biosafety Test
Probiotic Drug Tolerance Test
Our Advantages
- Effective process to ensure data quality
- Diverse personalized development services
- Rapid trial turnaround time
- Excellent professional project design and planning
With a solid foundation of microbiological experts and edible drug engineering researchers, our company is committed to providing you with high-end professional services for the development of probiotic therapy for Autoimmune Diseases & Inflammation. If you are interested in our services, please don't hesitate to contact us.
Reference
- Mazziotta, Chiara et al. "Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health." Cells 12,1 (2023): 184.