Stem Cell Therapy Development Service
Stem cell therapy, which has attracted much attention due to its unique ability to differentiate into various cell types and proliferate widely, utilizes stem cells to repair, replace, or restore damaged or diseased cells and tissues in the body. CD BioSciences provides state-of-the-art research services to help you rapidly design and develop highly effective stem cells therapies for Autoimmune Diseases & Inflammation.
Stem Cells Therapy in Autoimmune Diseases & Inflammation
The application of stem cell therapy in Autoimmune Diseases & Inflammation is an area of intense research, which has made different progress in a variety of diseases. According to the cell source, the stem cells can be divided into embryonic stem cells, adult stem cells and induced pluripotent stem cells.
Embryonic Stem Cells (ESCs)
ESCs are derived from the inner cell mass of blastocysts prepared by cloning or in vitro fertilization. The ESCs are capable of differentiating indefinitely into any cell type in the body, and are capable of continuously dividing to produce new stem cells. With these characteristics, several trials of autoimmune diseases have confirmed the advantages of ESCs. While the application of ESCs remains costly and may involve ethical issues.
Adult Stem Cells (ASCs)
ASCs exist widely in adult tissues, including bone marrow, fat, muscle, skin, nerve, etc. The ASCs can differentiate into specific cell types with limited differentiation potential. Hematopoietic stem cells (HSCs) have been used to treat autoimmune diseases in an earlier era. In recent years, the non-hematopoietic stem cells, such as mesenchymal stromal cells (MSCs) and neural stem cells (NSCs), have shown significant advantages in the therapeutics of various diseases.
- HSC-based therapy aims to provide healthy hematopoietic stem cells to restore a abnormal or damaged hematopoietic system, which is especially suitable for the therapeutics of hematological autoimmune diseases and bone marrow diseases. It has been shown to have a potential role in the therapeutics of neurological diseases presenting a large class of inflammatory factors.
- MSC-based therapy is one of the most widely studied and applied for autoimmune diseases. The MSCs can be differentiated into bone, fat, cartilage and other cells, and have been used in diseases involving bone and cartilage damage, osteoarthritis. Moreover, MSCs themselves also perform a variety of functions to regulate the immune system, including anti-fibrosis, anti-apoptosis, neuroprotection and immunomodulation.
- NSC-based therapy is an effective therapeutic strategy for neurodegenerative diseases. Mechanisms such as the production of neurotrophic factors, reduction of neuroinflammation, enhancement of neuronal plasticity, and cell replacement have led to promising results of NSCs in early trials.
Induced Pluripotent Stem Cells (iPSCs)
Induced Pluripotent Stem Cells (iPSCs) iPSCs have the ability to produce an unlimited number of designated cells that can replace damaged or dead cells in the immune system to perform their intrinsic function of regulating inflammation. In addition, they can also be used as autologous cells for in vitro disease modeling and personalized therapeutics, avoiding the problem of immune rejection.
Fig.1
Mechanisms of action for non-hematopoietic stem cells (Smith et al. 2021)
Stem Cells Transplants
In the final application of stem cell therapy, two main therapies have been selected for the transplantation of predetermined stem cells for patients with autoimmune diseases, depending on the specific disease type, the physical condition of the patient, the need for treatment, and the resources available. Both the allogeneic and autologous transplants are being explored for the treatment of autoimmune diseases, and have been shown expected results in multiple sclerosis, scleroderma, psoriatic arthritis, etc.
Our Services
As a regenerative medicine technology, stem cell therapy has great potential in the treatment of autoimmune diseases and inflammation. With comprehensive cell culture and cell engineering software and hardware, CD BioSciences provides cell therapy development utilizing distinct stem cell types, including but not limited to:
ASCs derived from:
iPSCs induced from:
Workflow of Stem Cell Therapy Development
Our Advantages
- Professional and experienced technical team
- High quality and high quantity guarantee
- Full range of innovative program services
- High quality of optimization effect
With the involvement of leading researchers in stem cell engineering biology with extensive experience in stem cell therapy, CD BioSciences wholeheartedly provides you with professional services for the stem cells therapy development for Autoimmune Diseases & Inflammation. Please contact us for more detailed information and our team will get back to you promptly.
Reference
- Smith JA, et al. Stem Cell Therapies for Progressive Multiple Sclerosis. Front Cell Dev Biol, 2021, 9:696434