Cardiovascular System Diseases
The cardiovascular system plays a crucial role in maintaining the proper functioning of the human body. However, it is susceptible to various autoimmune and inflammatory diseases that can significantly impact cardiovascular health. Our company is at the forefront of cardiovascular system autoimmune and inflammation diseases drug and therapy development services.
Overview of Cardiovascular System Autoimmune Diseases
Cardiovascular system autoimmune and inflammatory diseases encompass a range of conditions characterized by abnormal immune responses and inflammation that target the cardiovascular system. These diseases can affect various components of the cardiovascular system, such as the heart, blood vessels, and surrounding tissues. Several key targets have been identified, including cytokines, chemokines, immune cells, and signaling molecules involved in the inflammatory response. Examples of cardiovascular system autoimmune and inflammatory diseases include autoimmune hemolytic anemia, immune thrombocytopenia, and pure red cell aplasia.
- Autoimmunity in Cardiovascular System Diseases
Autoimmune diseases involve a dysregulated immune response, where the immune system mistakenly recognizes self-components as foreign and launches an attack against them. In the context of cardiovascular system diseases, autoimmunity can result in chronic inflammation, tissue damage, and vascular dysfunction.
Fig.1 IL-10 in cardiovascular system autoimmune and inflammation diseases. (Goswami S. K., et al., 2021)
Value of Therapy Development for Cardiovascular System Autoimmune Diseases
Research has consistently demonstrated a heightened risk of cardiovascular disease among individuals with autoimmune conditions. Notably, those with systemic sclerosis, Addison's disease, systemic lupus erythematosus, and type 1 diabetes face the greatest susceptibility. Recognizing this growing concern, leading pharmaceutical companies are increasingly investing in the development of therapies specifically targeting autoimmune diseases affecting the cardiovascular system. Encouragingly, the table below showcases several drugs that have been successfully developed to address these conditions.
| Condition (Cardiovascular System Diseases) | Drug | Target | Structure | Organization |
|---|---|---|---|---|
| Ecurrent Pericarditis | Anakinra | IL-1 | IL-1R antagonist | Swedish Orphan Biovitrum |
| Ecurrent Pericarditis | Rilonacept | IL-1 | IL-1R1-IgG Fc | Kiniksa Pharmaceuticals |
| Granulomatosis with Polyangiitis / Microscopic Polyangiitis | Rituximab | B cell | Anti-CD20 mAb | Roche |
Our Services
At our company, we offer a comprehensive range of services for cardiovascular system autoimmune and inflammatory diseases diagnostic and therapy development. We employ cutting-edge techniques to identify novel targets, design therapeutic agents, and optimize therapy protocols.
Types of Cardiovascular System Autoimmune Diseases
With our diversified therapy development platform, our company provides customized therapy development services for different types of diseases to meet all your needs.
Validating therapeutic approaches in relevant animal models is crucial for the development of cardiovascular system autoimmune and inflammatory disease therapies. Our company focuses on developing animal models that simulate human diseases to support our preclinical research services. If you are interested in our services, please don't hesitate to contact us.
Reference
- Goswami S. K., et al. "Management of inflammation in cardiovascular diseases." Pharmacological research 173 (2021): 105912.