Parsonage-Turner Syndrome
Parsonage-Turner syndrome, also known as neuralgic amyotrophy, acute brachial neuropathy, and abbreviated PTS, is a rare neurological disorder characterized by sudden onset shoulder pain, muscle weakness, and sensory deficits. At our company, we are committed to advancing drug and therapy development services for PTS.
Introduction to Parsonage-Turner Syndrome
Parsonage-Turner syndrome (PTS) is a neurological disorder characterized by the sudden onset of severe shoulder pain, followed by weakness and sensory abnormalities in the affected arm. The exact cause of PTS remains elusive, with no single etiological factor identified. However, it is believed to involve an autoimmune-mediated response triggered by various factors such as viral infections, surgery, trauma, or vaccination. The syndrome primarily affects the brachial plexus, a network of nerves responsible for motor and sensory innervation of the upper limb.
Fig.1 Anterior interosseus neuropathy in Parsonage-Turner syndrome. (Meiling J. B., et al., 2024)
Therapy Discovery and Development for Parsonage-Turner Syndrome
Currently, the therapeutics of Parsonage-Turner syndrome focus on alleviating pain, reducing inflammation, and promoting functional recovery. Drug therapy options include nonsteroidal anti-inflammatory drugs (NSAIDs) for pain management, corticosteroids to suppress the immune response, and neuroleptics for symptom relief. While some studies suggest the potential benefits of oral steroids, further research is needed to establish their efficacy in treating PTS. In addition to drugs, physical therapy plays a vital role in the rehabilitation process for individuals with PTS. Modalities such as transcutaneous electrical nerve stimulation (TENS) and acupuncture can help manage pain and improve muscle function.
With rich experience, our company has professional technology and a platform to provide you with suitable PTS diagnostics and therapy development solutions. If you want to learn more, please click the link below.
Our Services
Leveraging our extensive knowledge and experience, our renowned organization offers a comprehensive and inclusive range of services dedicated to the development of therapies targeting PTS. We take great pride in our ability to provide a seamless and effective approach that is tailored to meet your specific needs.
To better evaluate potential therapeutics, our company specializes in the development of animal models and in vitro models for Parsonage-Turner syndrome. Animal models provide a controlled environment to study the disease progression, investigate underlying mechanisms, and assess the efficacy of novel therapies. Additionally, our in vitro models allow for the study of specific cellular and molecular interactions involved in Parsonage-Turner syndrome.
Surgical Animal Models
Surgical animal models involve the manipulation of the brachial plexus, the affected nerve network in PTS. By surgically inducing nerve damage similar to that observed in PTS cases, we can test potential therapeutic interventions.
Through our cell-based model development service, our company offers the creation of in vitro models using primary cells or cell lines derived from relevant tissues, such as peripheral nerves or muscle cells.
Organoids can recapitulate the cellular diversity, architecture, and functionality of the tissue of interest. By utilizing patient-derived cells or genetically modified cells, we can develop organoids that closely resemble the characteristics of PTS.
Through rigorous experimentation, data analysis, and collaborative partnerships, we aim to identify promising drug candidates and therapeutic strategies for further development. In addition to the extensive array of services and models mentioned earlier, our proficiency extends to tailoring personalized solutions and creating disease models that precisely cater to your specific requirements. We take pride in our ability to adapt and customize our offerings to meet your unique needs. If our comprehensive range of services has captured your attention, we sincerely welcome you to reach out to us without any hesitation.
Reference
- Meiling James B., et al. "Parsonage-Turner Syndrome and Hereditary Brachial Plexus Neuropathy." Mayo Clinic Proceedings. Vol. 99. No. 1. Elsevier, 2024.