Respiratory System Diseases
Respiratory system autoimmune and inflammatory diseases are a group of disorders characterized by abnormal immune responses and inflammation within the respiratory system. Our company is at the forefront of providing innovative solutions in this field, offering comprehensive diagnostics, therapy development, animal model development, and preclinical research services.
Introduction to Respiratory System Autoimmune Diseases
Respiratory system autoimmune and inflammatory diseases encompass a diverse array of conditions that impact different components of the respiratory system, including the lungs, airways, and surrounding tissues. These diseases arise due to an aberrant immune response, where the body's immune system erroneously targets and attacks normal cells and tissues within the respiratory system. This immune dysregulation sets off a cascade of chronic inflammation, resulting in tissue damage and compromising respiratory function. The intricate interplay between immune dysfunction and the respiratory system's physiological processes underscores the complexity of these diseases.
Fig.1 Overview of immune-mediated lung diseases. (Sweis J. J. G., et al., 2023)
Value of Therapy Development for Respiratory System Autoimmune Diseases
Susceptible individuals may experience the development and progression of these conditions due to a combination of various environmental triggers. Exposure to specific allergens, pollutants, infections, and smoking are among the environmental factors believed to have a role in initiating and exacerbating respiratory system autoimmune and inflammatory diseases. A comprehensive understanding of the disease's pathogenesis is crucial for the accurate development of targeted therapies. A growing number of pharmaceutical companies are involved in research and development of drugs and therapies for autoimmune respiratory diseases.
| Condition (Respiratory System Autoimmune Diseases) | Drug Name | Organization | Status |
|---|---|---|---|
| Asthma | Dalazatide | Kineta | Preclinical |
| Interstitial Lung Diseases | Belimumab | GSK | Phase II/III |
| Chronic Obstructive Pulmonary Disease | Acetylcysteine | Zambon | Phase III |
| Allergic Rhinitis | Omalizumab | Genentech | Phase III |
| Asthma | Omalizumab | Genentech | Sale |
Our Services
At our company, we utilize advanced diagnostic techniques, including genetic testing, immunological profiling, and biomarker analysis, to accurately diagnose respiratory system autoimmune and inflammatory diseases. These tests aid in identifying specific disease subtypes, predicting disease progression, and guiding personalized therapy selection.
Our team of experts develops and validates animal models that closely mimic the pathological features and immune dysregulation seen in respiratory system autoimmune and inflammatory diseases. These models serve as valuable tools for studying disease mechanisms, screening potential therapies, and assessing therapeutic efficacy. If you are interested in our services, please don't hesitate to contact us.
Reference
- Sweis J. J. G., et al. "Immune-mediated lung diseases: A narrative review." Frontiers in Medicine 10 (2023): 1160755.