Nervous System Diseases
Nervous system autoimmune and inflammatory diseases encompass a diverse group of disorders characterized by aberrant immune responses targeting the central and peripheral nervous systems. Through the identification of therapeutic targets, the development of specific drug therapies, and the utilization of animal models and preclinical research services, our company is at the forefront of diagnostic and therapeutic advancements in this field.
Introduction to Nervous System Autoimmune Diseases
Nervous system autoimmune and inflammatory diseases are a group of disorders characterized by immune-mediated inflammation in different regions of the central and peripheral nervous systems. These conditions can affect various components of the nervous system, including the brain, spinal cord, peripheral nerves, and neuromuscular junctions. Examples of such diseases include multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), Guillain-Barré syndrome (GBS), and chronic inflammatory demyelinating polyneuropathy (CIDP).
Targets of Nervous System Autoimmune Diseases Therapy
- Tumor Necrosis Factor (TNF)
- IL-6 Receptor
- B cells
- Complement System
Autonomic Nervous System and Immunity
- Innate Immunity
The innate immune system serves as the body's first line of defense against pathogens and damaged cells. Toll-like receptors (TLRs) and other receptors play a pivotal role in activating innate immune responses. Within this context, the autonomic nervous system (ANS) plays a crucial modulatory role.
- Adaptive Immunity
The adaptive immune response involves the recognition of specific antigens by lymphocytes, such as T cells and B cells, ultimately leading to a targeted immune response. The involvement of the ANS in adaptive immunity is multifaceted and plays a crucial role in maintaining immune tolerance and preventing autoimmunity.
Fig.1 The role of nerves in the immune system. (Bellocchi C., et al., 2022)
Value of Therapy Development for Nervous System Autoimmune Diseases
Age plays a significant role in the development of autoimmune diseases affecting the nervous system. Specific neurological autoimmune disorders are more prevalent within certain age groups. For instance, multiple sclerosis commonly manifests between the ages of 20 and 40, whereas Parkinson's disease typically occurs after the age of 50. In order to develop more precise and targeted drugs, a comprehensive understanding of the disease population and underlying pathogenesis is imperative. Consequently, numerous pharmaceutical companies have made substantial investments in the research and development of drugs and therapies for neurological autoimmune diseases. This competitive landscape reflects their determination to seize the market opportunity and provide effective therapeutic options for diseases.
| Condition (Nervous System Autoimmune Diseases) | Drug Name | Organization | Status |
|---|---|---|---|
| Encephalitis, Chronic Focal (Rasmussen's Encephalitis) | Rituximab | Genentech | Phase II |
| Encephalitis, Chronic Focal (Rasmussen's Encephalitis) | Tacrolimus | Astellas Pharma | Phase II/III |
| Myasthenia Gravis | Ciclosporin | Novartis | Sale |
| Behcet's disease | Infliximab | Mitsubishi Tanabe Pharma | Sale |
Our Services
As a leading company in the field of pharmaceuticals and autoimmune diseases, our company is dedicated to advancing diagnostic and therapy development for nervous system autoimmune and inflammatory diseases. We develop state-of-the-art diagnostic tools to help accurately and early detect these diseases to provide you with more precise therapeutic development solutions.
Animal models play a crucial role in understanding the mechanisms underlying nervous system autoimmune and inflammatory diseases and evaluating the efficacy and safety of potential drug therapies. At our company, we have established expertise in animal model development for these diseases. By utilizing genetically modified animals or inducing disease-like symptoms in animals, we can replicate the pathological processes observed in human patients.
Types of Nervous System Autoimmune Diseases
If you are interested in our services, please don't hesitate to contact us.
Reference
- Bellocchi C., et al. "The interplay between autonomic nervous system and inflammation across systemic autoimmune diseases." International Journal of Molecular Sciences 23.5 (2022): 2449.
- Lapides D. A., and McDonald M.M. "Inflammatory manifestations of systemic diseases in the central nervous system." Current Treatment Options in Neurology 22 (2020): 1-15.