Pelvic Inflammatory Disease
The advancement of efficacious drugs and therapies for a wide range of autoimmune diseases holds immense significance. Among these diseases, pelvic inflammatory disease (PID) stands as a significant global health issue predominantly affecting women. At our company, we have honed our expertise in delivering comprehensive services dedicated to the development of targeted drugs and therapies for PID.
Introduction to Pelvic Inflammatory Disease
Pelvic inflammatory disease (PID), also referred to as pelvic inflammatory disorder, is a distressing condition characterized by infection and inflammation of the female reproductive organs. The uterus, fallopian tubes, and ovaries are primarily affected by this condition. The main cause of PID is the ascent of infection from the lower genital tract, often resulting from sexually transmitted infections (STIs) like Chlamydia trachomatis and Neisseria gonorrhoeae. The consequences of PID can be severe, leading to complications such as chronic pelvic pain, infertility, and ectopic pregnancy.
Fig.1 Pathogenesis of pelvic inflammatory disease caused by Neisseria gonorrhoeae and Chlamydia trachomatis. (Darville T., 2021)
Therapy Discovery and Development for Pelvic Inflammatory Disease
Antibiotics are the cornerstone of PID therapeutic, targeting the causative microorganisms. The choice of antibiotics depends on the suspected pathogens and local resistance patterns. Regimens typically involve broad-spectrum antibiotics that cover both aerobic and anaerobic bacteria. In severe cases, hospitalization and intravenous administration of antibiotics may be required. Additionally, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate pain and reduce inflammation.
At our company, we offer a comprehensive range of services to support the development of diagnostics and therapies for pelvic inflammatory disease. To gain a deeper understanding of each specific service we provide, we encourage you to click on the links below.
Our Services
Precise animal models and in vitro models play a pivotal role in comprehending the pathogenesis of pelvic inflammatory disease (PID) and evaluating the effectiveness of potential therapeutics. At our company, we possess specialized expertise in crafting dependable and consistent animal models that faithfully replicate the disease conditions observed in human cases. Additionally, our meticulously designed in vitro models provide a controlled setting for investigating the cellular and molecular interactions that are relevant to PID.
Ureaplasma Urealyticum
Induced Models
Ureaplasma urealyticum liquids are administered via vaginal injection, combined with inducing fatigue and hunger in the mice or rabbits. This combination allows us to simulate the physiological conditions that may contribute to the development and progression of pelvic inflammatory disease (PID).
Chlamydia trachomatis
NHP Models
We develop NHP models using species such as marmosets, grivet monkeys, pigtailed macaques, cynomolgus monkeys, rhesus monkeys, and baboons. In these models, we directly inoculate the reproductive tracts of NHPs with C. trachomatis to replicate the pathological and immunological features observed in humans with PID.
We carefully choose cell lines that reflect the characteristics of the target tissues affected by PID, such as the fallopian tubes and endometrium. Commonly used cell lines include human fallopian tube epithelial cells (FTSECs), endometrial epithelial cells, and immune cells such as macrophages or neutrophils.
To develop organoid models for pelvic inflammatory disease (PID), we culture and differentiate stem cells or tissue-specific cells into three-dimensional organoids. For example, we can generate fallopian tube organoids or endometrial organoids using patient-derived cells or cell lines.
In addition to the extensive array of services and models discussed earlier, our company excels in creating personalized solutions and designing disease models that are precisely tailored to your specific needs. We take immense pride in our capacity to adapt and customize our offerings to cater to the individual requirements of each client. If our comprehensive range of services has captured your interest, we wholeheartedly urge you to reach out to us without any hesitation.
References
- Darville Toni. "Pelvic inflammatory disease due to Neisseria gonorrhoeae and Chlamydia trachomatis: immune evasion mechanisms and pathogenic disease pathways." The Journal of infectious diseases 224.Supplement_2 (2021): S39-S46.
- Gradison Margaret. "Pelvic inflammatory disease." American family physician 85.8 (2012): 791-796.