Preclinical Research Services
Autoimmune diseases and inflammation are complex conditions that require extensive research and development of effective therapeutic interventions. Before new therapeutics can be administered to humans, they undergo a rigorous evaluation process known as preclinical research. At our company, we provide comprehensive preclinical study services specifically designed for autoimmune diseases and inflammation research.
Introduction to Preclinical Research
Preclinical research are an essential step in the drug development process, conducted before human clinical trials. These studies involve in vitro and in vivo experiments to assess the safety and efficacy of potential therapeutic interventions. The primary objective of preclinical research is to gather data on drug toxicity, pharmacokinetics, and biological activity to support the decision-making process for advancing a drug candidate to clinical trials.
Fig.1 Comparison of exploratory (hypothesis generating) and confirmatory (hypothesis testing) preclinical research. (Huang W., et al., 2020)
Preclinical Research Design
Preclinical study design involves careful planning and execution to meet the specific objectives of evaluating a drug candidate. Here are the main considerations in designing a preclinical research:
- Study Objectives: Clearly define the goals and endpoints of the study, such as assessing safety, efficacy, or both.
- Study Design: Determine the appropriate experimental design, including the choice of animal models, therapeutic groups, and control groups.
- Dosage Selection: Establish the appropriate dosage levels to be used in the study, considering factors such as therapeutic index, pharmacokinetic data, and potential adverse effects.
- Statistical Analysis: Plan the statistical analysis methods to ensure the reliability and validity of the study results.
- Ethical Considerations: Comply with ethical guidelines and regulations regarding animal welfare and care during the preclinical research.
- Endpoints and Measurements: Identify the specific endpoints and measurements to be assessed, such as biomarkers, histopathological analysis, immunological responses, or experimental observations.
Our Services
At our company, we are committed to advancing research in autoimmune diseases and inflammation through our preclinical study services. Specifically tailored for this field, our services encompass a wide range of evaluations and assessments to support the development of effective therapies.
Types of Preclinical Research
Types of Autoimmune and Inflammation Diseases
Why Choose Us?
Our experienced team utilizes state-of-the-art technology and rigorous scientific protocols designed to provide accurate and reliable results for preclinical research. These studies can help optimize drugs and therapies for autoimmune diseases and inflammation, improving efficacy and safety. If you are interested in our services, please don't hesitate to contact us.
Reference
- Huang W., et al. "General principles of preclinical study design." Good research practice in non-clinical pharmacology and biomedicine (2020): 55-69.